9PB5

Human TRPM8 menthol bound structure at 4 degrees Celsius resolved in cell vesicles using cryo-EM

Summary for 9PB5

• Entry DOI: 10.2210/pdb9pb5/pdb
• EMDB information: 71454
• Descriptor: Transient receptor potential cation channel subfamily M member 8, (1R,2S,5R)-5-methyl-2-(propan-2-yl)cyclohexan-1-ol (2 entities in total)
• Functional Keywords: trpm8, transient receptor potential melastatin 8, membrane protein, human, menthol
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 4
• Total formula weight: 513961.94

Authors

Choi, K.Y.,Lin, X.,Cheng, Y.,Julius, D. (deposition date: 2025-06-26, release date: 2026-03-25)

• Primary citation: Choi, K.Y.,Lin, X.,Cheng, Y.,Julius, D.; Structural energetics of cold sensitivity; Nature, 2026; DOI: 10.1038/s41586-026-10276-2

Experimental method

ELECTRON MICROSCOPY (3.5 Å)