9PAR

Avian TRPM8 (Parus major) semi-swapped, ligand-free structure at high pH and 4 degrees Celsius resolved in GDN using cryo-EM

Summary for 9PAR

• Entry DOI: 10.2210/pdb9par/pdb
• EMDB information: 71444
• Descriptor: Transient receptor potential cation channel subfamily M member 8, [(2R)-1-octadecanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phospho ryl]oxy-propan-2-yl] (8Z)-icosa-5,8,11,14-tetraenoate (2 entities in total)
• Functional Keywords: trpm8, transient receptor potential melastatin 8, membrane protein
• Biological source: Parus major (Great Tit)
• Total number of polymer chains: 4
• Total formula weight: 513056.42

Authors

Choi, K.Y.,Lin, X.,Cheng, Y.,Julius, D. (deposition date: 2025-06-25, release date: 2026-03-25)

• Primary citation: Choi, K.Y.,Lin, X.,Cheng, Y.,Julius, D.; Structural energetics of cold sensitivity; Nature, 2026; DOI: 10.1038/s41586-026-10276-2

Experimental method

ELECTRON MICROSCOPY (3 Å)