9OUL

DDB1-CRBN with Ikaros(ZF2), SB-405483, and DEG-47: composite map and model submission

This is a non-PDB format compatible entry.

Summary for 9OUL

• Entry DOI: 10.2210/pdb9oul/pdb
• EMDB information: 70870
• Descriptor: DNA damage-binding protein 1, Protein cereblon, ZINC ION, ... (5 entities in total)
• Functional Keywords: e3 ligases, cullin ring ligase, crl4, cereblon, crbn, molecular glues, imids, ligase, ikaros
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 145069.27

Authors

Rizvi, Z.,Lander, G.C. (deposition date: 2025-05-28, release date: 2025-11-19, Last modification date: 2025-12-24)

• Primary citation: Rizvi, Z.,Dippon, V.N.,Choudhry, A.E.,Chung, C.W.,Alkuraya, A.F.,Xu, W.,Tao, X.B.,Jurewicz, A.J.,Schneck, J.L.,Chen, W.,Curnutt, N.M.,Kabir, F.,Chan, K.H.,Queisser, M.A.,Musetti, C.,Dai, H.,Benowitz, A.B.,Woo, C.M.,Lander, G.C.; Identification of a cryptic allosteric site on the E3 ligase adapter protein cereblon; Nature, 2025; DOI: 10.1038/s41586-025-09994-w

Experimental method

ELECTRON MICROSCOPY (2.97 Å)