9OUL

DDB1-CRBN with Ikaros(ZF2), SB-405483, and DEG-47: composite map and model submission

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	DNA damage-binding protein 1	polymer	844	94389.2	1	UniProt (Q16531) Pfam (PF10433) Pfam (PF03178)	Homo sapiens (human)	DDB p127 subunit,DNA damage-binding protein a,DDBa,Damage-specific DNA-binding protein 1,HBV X-associated protein 1,XAP-1,UV-damaged DNA-binding factor,UV-damaged DNA-binding protein 1,UV-DDB 1,XPE-binding factor,XPE-BF,Xeroderma pigmentosum group E-complementing protein,XPCe
2	B (C)	Protein cereblon	polymer	434	49890.9	1	UniProt (Q96SW2) Pfam (PF02190) Pfam (PF03226)	Homo sapiens (human)
3	C (C)	ZINC ION	non-polymer		65.4	1	Chemie (ZN)
4	D (C)	N-[3-(benzyloxy)pyridin-2-yl]-N'-(4-cyano-2-hydroxyphenyl)urea	non-polymer		360.4	1	Chemie (A1CEG)
5	E (C)	N-{2-[(3S)-2,6-dioxopiperidin-3-yl]-1-oxo-2,3-dihydro-1H-isoindol-5-yl}benzamide	non-polymer		363.4	1	Chemie (A1CEK)

Sequence modifications

A: 1 - 699 (UniProt: Q16531)
A: 706 - 1140 (UniProt: Q16531)

PDB	External Database	Details
Gly 700	-	linker
Asn 701	-	linker
Gly 702	-	linker
Asn 703	-	linker
Ser 704	-	linker
Gly 705	-	linker
Trp 1141	-	expression tag
Ser 1142	-	expression tag
His 1143	-	expression tag
Pro 1144	-	expression tag
Gln 1145	-	expression tag
Phe 1146	-	expression tag
Glu 1147	-	expression tag
Lys 1148	-	expression tag

C: 1 - 427 (UniProt: Q96SW2)

PDB	External Database	Details
Met -6	-	initiating methionine
His -5	-	expression tag
His -4	-	expression tag
His -3	-	expression tag
His -2	-	expression tag
His -1	-	expression tag
His 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	144280.1
Non-Polymers*	Number of molecules	3
	Total formula weight	789.1
All*	Total formula weight	145069.3

*Water molecules are not included.