9OS2

Cryo-EM structure of the DDB1/CRBN-MRT-5702-G3BP2 ternary complex

This is a non-PDB format compatible entry.

Summary for 9OS2

• Entry DOI: 10.2210/pdb9os2/pdb
• EMDB information: 70791
• Descriptor: Protein cereblon, DNA damage-binding protein 1, Ras GTPase-activating protein-binding protein 2, ... (5 entities in total)
• Functional Keywords: molecular glue degrader, neo-substrate, cereblon, e3 ubiquitin ligase, ligase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 279734.21

Authors

Quan, C.,Petzold, G.,Gainza, P.,Tsai, J.,Bunker, R.D.,Wiedmer, L.,Donckele, E.J. (deposition date: 2025-05-23, release date: 2026-01-28)

• Primary citation: Annunziato, S.,Quan, C.,Donckele, E.J.,Lamberto, I.,Bunker, R.D.,Zlotosch, M.,Schwander, L.,Murthy, A.,Wiedmer, L.,Staehly, C.,Matysik, M.,Gilberto, S.,Kapsitidou, D.,Wible, D.,de Donatis, G.D.,Trenh, P.,SriRamaratnam, R.,Strande, V.,Almeida, R.,Dolgikh, E.,DeMarco, B.,Tsai, J.,Sadok, A.,Zarayskiy, V.,Walter, M.,Tiedt, R.,Lumb, K.J.,Bonenfant, D.,Fasching, B.,Castle, J.C.,Townson, S.A.,Petzold, G.,Gainza, P.; Cereblon induces G3BP2 neosubstrate degradation using molecular surface mimicry; Nat.Struct.Mol.Biol., 2026; DOI: 10.1038/s41594-025-01738-8

Experimental method

ELECTRON MICROSCOPY (2.5 Å)