9OLX

Structure of a constitutively open human TRPC3 mutant in the inhibited state

This is a non-PDB format compatible entry.

Summary for 9OLX

• Entry DOI: 10.2210/pdb9olx/pdb
• EMDB information: 70601
• Descriptor: Short transient receptor potential channel 3, UNKNOWN LIGAND, (3,4-dihydroisoquinolin-2(1H)-yl)[2-(4-methoxyanilino)-1,3-thiazol-4-yl]methanone (3 entities in total)
• Functional Keywords: trpc3, cerebellar ataxia, moonwalker, membrane protein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 4
• Total formula weight: 382459.81

Authors

Bell, B.,Baker, M.L.,Cordero-Morales, J.F. (deposition date: 2025-05-13, release date: 2026-03-25)

• Primary citation: Bell, B.,Jaramillo-Granada, A.M.,Romero, L.O.,Gutierrez, I.A.,Mallampalli, V.K.P.S.,Fan, G.,Varma, S.,Baker, M.L.,Serysheva, I.I.,Vasquez, V.,Cordero-Morales, J.F.; Functional and Structural Basis of a Hypermorphic TRPC3 variant; To Be Published,

Experimental method

ELECTRON MICROSCOPY (3.3 Å)