9OLX

Structure of a constitutively open human TRPC3 mutant in the inhibited state

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	Short transient receptor potential channel 3	polymer	820	94153.2	4	UniProt (Q13507)	Homo sapiens (human)	TrpC3,Transient receptor protein 3,TRP-3,hTrp-3,hTrp3
2	E, F, G, I, J... (A, B, C, D)	UNKNOWN LIGAND	non-polymer		365.4	12	Chemie (UNL)
3	H, L, P, R (A, B, C, D)	(3,4-dihydroisoquinolin-2(1H)-yl)[2-(4-methoxyanilino)-1,3-thiazol-4-yl]methanone	non-polymer		365.4	4	Chemie (A1CCX)

Sequence modifications

A, B, C, D: 1 - 838 (UniProt: Q13507)

PDB	External Database	Details
Ala 573	Thr 646	engineered mutation
-	Leu 822	deletion
-	Asn 823	deletion
-	Leu 824	deletion
-	Phe 825	deletion
-	Thr 826	deletion
-	Gln 827	deletion
-	Ser 828	deletion
-	Asn 829	deletion
-	Ser 830	deletion
-	Arg 831	deletion
-	Val 832	deletion
-	Phe 833	deletion
-	Glu 834	deletion
-	Ser 835	deletion
-	His 836	deletion
-	Ser 837	deletion
-	Phe 838	deletion
-	Asn 839	deletion
-	Ser 840	deletion
-	Ile 841	deletion
-	Leu 842	deletion
-	Asn 843	deletion
-	Gln 844	deletion
-	Pro 845	deletion
-	Thr 846	deletion
-	Arg 847	deletion
-	Tyr 848	deletion
-	Gln 849	deletion
Ile 839	-	expression tag
Ser 840	-	expression tag
Ser 841	-	expression tag
Leu 842	-	expression tag
Arg 843	-	expression tag
Tyr 844	-	expression tag
Glu 845	-	expression tag
Leu 846	-	expression tag
Leu 847	-	expression tag
Glu 848	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	376612.6
Non-Polymers*	Number of molecules	16
	Total formula weight	5847.2
All*	Total formula weight	382459.8

*Water molecules are not included.