9OB3

CDK2/CyclinE bound to compound 16 with P-loop in the EE conformation

This is a non-PDB format compatible entry.

Summary for 9OB3

• Entry DOI: 10.2210/pdb9ob3/pdb
• Descriptor: Cyclin-dependent kinase 2, G1/S-specific cyclin-E1, (1R,3R)-3-{3-[(pyrazine-2-carbonyl)amino]-1H-pyrazol-5-yl}cyclopentyl [(1S)-1-cyclopropylethyl]carbamate, ... (4 entities in total)
• Functional Keywords: cdk/cyclin, cell cycle
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 67850.83

Authors

Baird, J.,Holliday, M.H. (deposition date: 2025-04-22, release date: 2025-04-30)

• Primary citation: Douthwaite, J.L.,Houde, D.J.,Pardo, E.,Moran, M.S.,Baird, J.,Meyer, S.R.,Mahjour, B.,Zhao, Q.,Larrow, J.F.,Juang, Y.,Han, C.K.,Kelley, B.,Dunstan, D.R.,Holliday, M.J.,Billings, K.J.,Mader, M.M.,Taylor, A.M.,Sexton, J.Z.,Boezio, A.A.,Cernak, T.; Nanoscale direct-to-biology optimization of Cdk2 inhibitors; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.98 Å)