9OB3
CDK2/CyclinE bound to compound 16 with P-loop in the EE conformation
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Cyclin-dependent kinase 2 | polymer | 301 | 34412.9 | 1 | UniProt (P24941) Pfam (PF00069) | Homo sapiens (human) | Cell division protein kinase 2,p33 protein kinase |
| 2 | B (B) | G1/S-specific cyclin-E1 | polymer | 285 | 33053.5 | 1 | UniProt (P24864) Pfam (PF00134) Pfam (PF02984) | Homo sapiens (human) | |
| 3 | C (A) | (1R,3R)-3-{3-[(pyrazine-2-carbonyl)amino]-1H-pyrazol-5-yl}cyclopentyl [(1S)-1-cyclopropylethyl]carbamate | non-polymer | 384.4 | 1 | Chemie (A1CAH) | |||
| 4 | D, E (A, B) | water | water | 18.0 | 63 | Chemie (HOH) |
Sequence modifications
A: 1 - 298 (UniProt: P24941)
B: 96 - 378 (UniProt: P24864)
| PDB | External Database | Details |
|---|---|---|
| Ser -2 | - | expression tag |
| His -1 | - | expression tag |
| Met 0 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 94 | - | expression tag |
| Ser 95 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 67466.4 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 384.4 | |
| All* | Total formula weight | 67850.8 |
