9O36

CryoEM structure of mu-opioid receptor - Gi protein complex bound to fluornitrazene (FNZ)

This is a non-PDB format compatible entry.

Summary for 9O36

• Entry DOI: 10.2210/pdb9o36/pdb
• EMDB information: 70071
• Descriptor: Guanine nucleotide-binding protein G(i) subunit alpha-1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (6 entities in total)
• Functional Keywords: complex, receptor, agonist, mor, membrane protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 5
• Total formula weight: 162057.40

Authors

Robertson, M.J.,Skiniotis, G. (deposition date: 2025-04-05, release date: 2026-04-01)

• Primary citation: Gomez, J.L.,Ventriglia, E.N.,Frangos, Z.J.,Sulima, A.,Robertson, M.J.,Sacco, M.,Budinich, R.,Giosan, I.,Solis, O.,Tischer, A.E.,Bossert, J.M.,Caldwell, K.E.,Bonbrest, H.,Essmann, A.,Garcon-Poca, M.Z.,Choi, S.,Noya, M.R.,Glatfelter, G.,Robinson, M.,Mullarkey, A.A.,Brademan, D.R.,Enten, G.,Dunne, W.,Schoenborn, I.,Paule, J.,Rais, R.,Holt, D.P.,Dannals, R.F.,Tanda, G.,Newman, A.H.,Shi, L.,Huttenhain, R.,Ferre, S.,Kiyatkin, E.,Bonaventura, J.,Shaham, Y.,Zachariou, V.,Baumann, M.H.,Skiniotis, G.,Rice, K.C.,Michaelides, M.; A mu-opioid receptor superagonist analgesic with minimal adverse effects; Nature, 2026; DOI: 10.1038/s41586-026-10299-9

Experimental method

ELECTRON MICROSCOPY (2.3 Å)