9O35

Crystal structure of DoxA in complex with daunorubicin

Summary for 9O35

• Entry DOI: 10.2210/pdb9o35/pdb
• Descriptor: Cytochrome P-450 monooxygenase DoxA, PROTOPORPHYRIN IX CONTAINING FE, DAUNOMYCIN, ... (5 entities in total)
• Functional Keywords: p450 monooxygenase, hydroxylase, oxidoreductase
• Biological source: Streptomyces peucetius subsp. caesius ATCC 27952
• Total number of polymer chains: 2
• Total formula weight: 94512.54

Authors

Newmister, S.A.,Harte, R.J.,Kim, R.Q.,Metsa-Ketela, M.,Sherman, D.H. (deposition date: 2025-04-04, release date: 2025-12-24)

• Primary citation: Koroleva, A.,Artukka, E.,Yamada, K.,Newmister, S.A.,Harte, R.J.,Boesger, H.,Londen, M.,Sanders, J.N.,Tirkkonen, H.,Kannisto, M.,Kuin, R.C.M.,Hulst, M.,Wang, R.,Barillec, M.,Niemi, J.,van Wezel, G.P.,Neefjes, J.,Nybo, S.E.,Houk, K.N.,Sherman, D.H.,Kim, R.Q.,Metsa-Ketela, M.; Metabolic Engineering of Doxorubicin Biosynthesis: Advancing P450 Catalysis through Redox Partner2 Optimization and Structural Analysis of DoxA; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.19 Å)