9NYP

Cryo-EM structure of NVL bound the the MM927 inhibitor

This is a non-PDB format compatible entry.

Summary for 9NYP

• Entry DOI: 10.2210/pdb9nyp/pdb
• Related: 9BJI 9BJJ
• EMDB information: 49941
• Descriptor: Nuclear valosin-containing protein-like, polypeptide substrate mimic, ADENOSINE-5'-TRIPHOSPHATE, ... (7 entities in total)
• Functional Keywords: ribosome biogenesis, aaa+ atpase, translocase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 7
• Total formula weight: 580099.26

Authors

Cruz, V.E.,Erzberger, J.P. (deposition date: 2025-03-28, release date: 2026-04-29)

• Primary citation: Guo, H.H.,Tao, Y.,Cruz, V.E.,Fang, M.,Khivansara, V.,Xie, S.,Leach, A.,Rivera-Cancel, G.,Barrows, N.,Williams, N.,Aurora, A.,Erzberger, J.P.,De Brabander, J.K.,Nijhawan, D.; Optimized dibenzothiazepinones activate the impaired ribosome biogenesis checkpoint and trigger p53-dependent apoptosis by inhibiting the 60S assembly factor NVL; To Be Published,

Experimental method

ELECTRON MICROSCOPY (2.86 Å)