9NJA

Computationally optimized broadly reactive influenza B hemagglutinin BC2 bound by antibody #46

Summary for 9NJA

• Entry DOI: 10.2210/pdb9nja/pdb
• Related: 9NJ3 9NJ6 9NJ9
• EMDB information: 49463 49475 49476 49477
• Descriptor: Fab A Light Chain, Fab A Heavy Chain, Hemagglutinin, ... (5 entities in total)
• Functional Keywords: influenza, antibody, cell entry, hemagglutination, viral protein, viral protein-immune system complex, viral protein/immune system
• Biological source: Homo sapiens; More
• Total number of polymer chains: 9
• Total formula weight: 318883.98

Authors

Dzimianski, J.V.,Kunkel, I.,Balasco Serrao, V.H.,DuBois, R.M. (deposition date: 2025-02-27, release date: 2026-03-11, Last modification date: 2026-04-22)

Primary citation

Campos Mota, Y.,Dzimianski, J.V.,Lopez, M.,Richardson, R.A.,Ross, T.M.,Kunkel, I.J.A.,O'Rourke, S.M.,Balasco Serrao, V.H.,DuBois, R.M.,Sautto, G.A.
Human broadly neutralizing influenza B virus antibodies recognizing hemagglutinin computationally optimized broadly reactive antigens.
Front Immunol, 17:1747235-1747235, 2026

PubMed Abstract: Influenza B viruses (IBVs) are responsible for severe disease and death, similarly to influenza A viruses (IAVs), with a higher number of infections happening in children and the elderly. Despite the inclusion of an IBV component in the seasonal influenza vaccine, rates of vaccine effectiveness (VE) are still variable and low in many previous seasons.

PubMed: 41958660
DOI: 10.3389/fimmu.2026.1747235

Experimental method

ELECTRON MICROSCOPY (2.5 Å)