9NFS

Structure of J-PKAc chimera in complex with Aplithianine j1

Summary for 9NFS

Entry DOI	10.2210/pdb9nfs/pdb
Descriptor	cAMP-dependent protein kinase inhibitor alpha, DnaJ homolog subfamily B member 1,cAMP-dependent protein kinase catalytic subunit alpha, (4P)-4-[4-(pyrimidin-4-yl)-3,4-dihydro-2H-1,4-thiazin-6-yl]-1H-pyrrolo[2,3-b]pyridine (3 entities in total)
Functional Keywords	protein kinase a, fibrolamellar hepatocellular carcinoma, natural product, signaling protein, transferase
Biological source	Homo sapiens (human) More
Total number of polymer chains	4
Total formula weight	99907.53
Authors	Martinez Fiesco, J.A.,Zhang, P. (deposition date: 2025-02-21, release date: 2026-03-04)
Primary citation	Martinez Fiesco, J.A.,Zhang, P. Structure of J-PKAc chimera in complex with Aplithianine j1 To Be Published,
Experimental method	X-RAY DIFFRACTION (2.45 Å)

Structure validation