9NFS

Structure of J-PKAc chimera in complex with Aplithianine j1

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (D, C)	cAMP-dependent protein kinase inhibitor alpha	polymer	20	2226.4	2	UniProt (P61925)	Homo sapiens (human)	PKI-alpha,cAMP-dependent protein kinase inhibitor,muscle/brain isoform
2	C, D (A, B)	DnaJ homolog subfamily B member 1,cAMP-dependent protein kinase catalytic subunit alpha	polymer	405	47432.0	2	UniProt (P25685) UniProt (P17612) Pfam (PF00226) Pfam (PF00069)	Homo sapiens (human)	DnaJ protein homolog 1,Heat shock 40 kDa protein 1,HSP40,Heat shock protein 40,Human DnaJ protein 1,hDj-1,PKA C-alpha
3	E, F (A, B)	(4P)-4-[4-(pyrimidin-4-yl)-3,4-dihydro-2H-1,4-thiazin-6-yl]-1H-pyrrolo[2,3-b]pyridine	non-polymer		295.4	2	Chemie (A1BX1)

Sequence modifications

A, B: 1 - 69 (UniProt: P25685)
A, B: 70 - 405 (UniProt: P17612)

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	99316.8
Non-Polymers*	Number of molecules	2
	Total formula weight	590.7
All*	Total formula weight	99907.5

*Water molecules are not included.