9NFA

Cryo-EM structure of Ro60/La/minimal misfolded pre-5S rRNA complex with Fab, composite map

Summary for 9NFA

• Entry DOI: 10.2210/pdb9nfa/pdb
• EMDB information: 49360
• Descriptor: RNA-binding protein RO60, Lupus La protein, Minimal misfolded pre-5S rRNA, ... (4 entities in total)
• Functional Keywords: ro60 autoantigen, rna chaperone, rna folding, la autoantigen, rna binding protein, rna binding protein-rna complex, rna binding protein/rna
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 3
• Total formula weight: 129130.08

Authors

Nam, H.,Deme, J.C.,Lea, S.M.,Wolin, S.L. (deposition date: 2025-02-21, release date: 2026-02-04)

• Primary citation: Nam, H.,Deme, J.C.,Sim, S.,Boccitto, M.,Lea, S.M.,Wolin, S.L.; Mechanistic insights into RNA chaperoning by Ro60 and La autoantigens; Cell(Cambridge,Mass.), 2026; DOI: 10.1016/j.cell.2025.12.030

Experimental method

ELECTRON MICROSCOPY (2.7 Å)