9NE1

Crystal structure of a bacterial DOT1L methyl-transferase in complex with S-adenosyl homocysteine

Summary for 9NE1

• Entry DOI: 10.2210/pdb9ne1/pdb
• Descriptor: Histone-lysine N-methyltransferase, H3 lysine-79 specific, S-ADENOSYL-L-HOMOCYSTEINE (3 entities in total)
• Functional Keywords: methyl-transferase, product complex, bacteria, transferase
• Biological source: Legionella pneumophila
• Total number of polymer chains: 1
• Total formula weight: 26168.15

Authors

Mondino, S.,Dalla Rizza, J.,Larrieux, N.,Buschiazzo, A. (deposition date: 2025-02-19, release date: 2026-02-25)

• Primary citation: Nicchi, S.,Mondino, S.,Rusniok, C.,Danckaert, A.,Schoeler, H.,Martyn, E.J.,Dalla Rizza, J.,Larrieux, N.,Mahtal, N.,Quentin, G.G.,Matondo, M.,Buschiazzo, A.,Buchrieser, C.,Rolando, M.; A bacterial DOT1-like methyltransferase subverts paraspeckle dynamics and host cell splicing events; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.11 Å)