9NAL

Cryo-EM structure of ternary complex of human phosphoribosylglycinamidine synthase with the intermediate (iminophosphate) and ADP bound at the synthase site.

This is a non-PDB format compatible entry.

Summary for 9NAL

• Entry DOI: 10.2210/pdb9nal/pdb
• EMDB information: 49198
• Descriptor: Phosphoribosylformylglycinamidine synthase, ADENOSINE-5'-DIPHOSPHATE, N-[2-formamido-1-(phosphonooxy)ethylidene]-5-O-phosphono-beta-D-ribofuranosylamine, ... (5 entities in total)
• Functional Keywords: iminophosphate adp human phosphoribosylglycinamidine synthase, ligase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 149817.15

Authors

Sharma, N.,French, J.B. (deposition date: 2025-02-12, release date: 2026-02-25)

• Primary citation: Sharma, N.,Zhou, W.,French, J.B.; Structural and molecular basis for allosteric regulation and catalytic coupling of human phosphoribosylformylglycinamidine synthase; Nat Commun, 2026; DOI: 10.1038/s41467-026-69423-y

Experimental method

ELECTRON MICROSCOPY (3.22 Å)