9MXL

Complex of the phosphorylated human cystic fibrosis transmembrane conductance regulator (CFTR) with (R)-BPO-27 and ATP/Mg

This is a non-PDB format compatible entry.

Summary for 9MXL

• Entry DOI: 10.2210/pdb9mxl/pdb
• EMDB information: 48717
• Descriptor: Cystic fibrosis transmembrane conductance regulator, (6R,12R)-6-(5-bromofuran-2-yl)-7,9-dimethyl-8,10-dioxo-11-phenyl-7,8,9,10-tetrahydro-6H-pyrimido[4',5':3,4]pyrrolo[2,1-c][1,4]benzoxazine-2-carboxylic acid, MAGNESIUM ION, ... (6 entities in total)
• Functional Keywords: inhibitor, cftr, membrane protein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 169981.24

Authors

Young, P.G.,Fiedorczuk, K.,Chen, J. (deposition date: 2025-01-20, release date: 2025-08-06)

• Primary citation: Young, P.G.,Fiedorczuk, K.,Chen, J.; Structural basis for CFTR inhibition by (R)-BPO-27; To Be Published,

Experimental method

ELECTRON MICROSCOPY (2.1 Å)