9MXL
Complex of the phosphorylated human cystic fibrosis transmembrane conductance regulator (CFTR) with (R)-BPO-27 and ATP/Mg
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (B) | Cystic fibrosis transmembrane conductance regulator | polymer | 1480 | 168334.5 | 1 | UniProt (P13569) Pfam (PF00664) Pfam (PF00005) Pfam (PF14396) | Homo sapiens (human) | CFTR,ATP-binding cassette sub-family C member 7,Channel conductance-controlling ATPase,cAMP-dependent chloride channel |
| 2 | B (B) | (6R,12R)-6-(5-bromofuran-2-yl)-7,9-dimethyl-8,10-dioxo-11-phenyl-7,8,9,10-tetrahydro-6H-pyrimido[4',5':3,4]pyrrolo[2,1-c][1,4]benzoxazine-2-carboxylic acid | non-polymer | 548.3 | 1 | Chemie (A1BUJ) | |||
| 3 | C, D (B) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 4 | E, F (B) | ADENOSINE-5'-TRIPHOSPHATE | non-polymer | 507.2 | 2 | Chemie (ATP) | |||
| 5 | G (B) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 6 | H (B) | water | water | 18.0 | 6 | Chemie (HOH) |
Sequence modifications
B: 1 - 1480 (UniProt: P13569)
| PDB | External Database | Details |
|---|---|---|
| Gln 1371 | Glu 1371 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 168334.5 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1646.8 | |
| All* | Total formula weight | 169981.2 |
