9MW1

Structure of SARM1 TIR domain bound to G8758

Summary for 9MW1

Entry DOI	10.2210/pdb9mw1/pdb
Descriptor	NAD(+) hydrolase SARM1, [(2~{R},3~{S},4~{R},5~{R})-5-[4-[5-[(6~{R})-6-(4-chloranyl-3-fluoranyl-phenyl)-2-oxidanylidene-1,3-oxazinan-3-yl]-1~{H}-pyrazol-3-yl]pyridin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methyl phosphono hydrogen phosphate (3 entities in total)
Functional Keywords	sarm1, nadase, lyase
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	33742.87
Authors	Wallweber, H.A.,Sudhamsu, J. (deposition date: 2025-01-16, release date: 2026-02-04)
Primary citation	Wallweber, H.A.,Sudhamsu, J. Structure of SARM1 TIR domain bound to G8758 To Be Published,
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation