9MW1

Structure of SARM1 TIR domain bound to G8758

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (B, A)	NAD(+) hydrolase SARM1	polymer	143	16205.6	2	UniProt (Q6SZW1) Pfam (PF13676)	Homo sapiens (human)	NADase SARM1,hSARM1,NADP(+) hydrolase SARM1,Sterile alpha and Armadillo repeat protein,Sterile alpha and TIR motif-containing protein 1,Sterile alpha motif domain-containing protein 2,MyD88-5,SAM domain-containing protein 2,Tir-1 homolog,HsTIR
2	C, D (B, A)	[(2~{R},3~{S},4~{R},5~{R})-5-[4-[5-[(6~{R})-6-(4-chloranyl-3-fluoranyl-phenyl)-2-oxidanylidene-1,3-oxazinan-3-yl]-1~{H}-pyrazol-3-yl]pyridin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methyl phosphono hydrogen phosphate	non-polymer		665.9	2	Chemie (A1BTS)
3	E, F (B, A)	water	water		18.0	126	Chemie (HOH)

Sequence modifications

B, A: 560 - 700 (UniProt: Q6SZW1)

PDB	External Database	Details
Gly 558	-	expression tag
Ser 559	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	32411.1
Non-Polymers*	Number of molecules	2
	Total formula weight	1331.7
All*	Total formula weight	33742.9

*Water molecules are not included.