9MI0

61-12A01 Fab in complex with HIV-1 GT1.1 v4.1 SOSIP Env trimer and RM20A3 Fab

Summary for 9MI0

• Entry DOI: 10.2210/pdb9mi0/pdb
• EMDB information: 48283
• Descriptor: 61_12A01 heavy chain Fv, 61_12A01 kappa chain Fv, RM20A3 heavy chain Fv, ... (9 entities in total)
• Functional Keywords: hiv-1, sosip, germline targeting, vrc01, clinical trial, human, precursor antibody, viral protein
• Biological source: Homo sapiens; More
• Total number of polymer chains: 18
• Total formula weight: 392540.66

Authors

Phulera, S.,Ozorowski, G.,Ward, A.B. (deposition date: 2024-12-12, release date: 2025-05-21)

• Primary citation: Caniels, T.G.,Prabhakaran, M.,Ozorowski, G.,MacPhee, K.J.,Wu, W.,van der Straten, K.,Agrawal, S.,Derking, R.,Reiss, E.I.M.M.,Millard, K.,Turroja, M.,Desrosiers, A.,Bethony, J.,Malkin, E.,Liesdek, M.H.,van der Veen, A.,Klouwens, M.,Phulera, S.,Wilson, I.A.,Ward, A.B.; Precise targeting of HIV broadly neutralizing antibody precursors in humans; Science, 2025; DOI: 10.1126/science.adv5572

Experimental method

ELECTRON MICROSCOPY (2.8 Å)