9MHG

Cryo EM reconstruction of PI3KC3-C1 in complex with Human RAB1A(Q70L), VPS34 kinase domain in the inactive conformation

Summary for 9MHG

• Entry DOI: 10.2210/pdb9mhg/pdb
• EMDB information: 48277
• Descriptor: Phosphoinositide 3-kinase regulatory subunit 4, Phosphatidylinositol 3-kinase catalytic subunit type 3, Beclin 1-associated autophagy-related key regulator, ... (8 entities in total)
• Functional Keywords: complex, gtpase, gtp-binding, autophagy, kinase, lipid kinase, signaling protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 5
• Total formula weight: 394359.08

Authors

Cook, A.S.I.,Hurley, J.H.,Chen, M. (deposition date: 2024-12-11, release date: 2025-02-12)

• Primary citation: Cook, A.S.I.,Chen, M.,Ngyuen, T.N.,Claveras-Cabezudo, A.,Khuu, G.,Rao, S.,Garcia, S.N.,Yang, M.,Iavarone, A.T.,Ren, X.,Lazarou, M.,Hummer, G.,Hurley, J.H.; Structural pathway for class III PI 3-kinase activation by the myristoylated GTPbinding pseudokinase VPS15; To Be Published,

Experimental method

ELECTRON MICROSCOPY (3.2 Å)