9LLI

Cryo-EM structure of D1R in complex with de novo designed GEM targeting TM1/2/4 and GEM targeting TM3/4/5, and negative allosteric GEM targeting TM5/6/7

This is a non-PDB format compatible entry.

Summary for 9LLI

• Entry DOI: 10.2210/pdb9lli/pdb
• EMDB information: 63203
• Descriptor: D(1A) dopamine receptor, De novo designed GPCR exoframe modulator targeting TM1/2/4, De novo designed GPCR exoframe modulator targeting TM3/4/5, ... (5 entities in total)
• Functional Keywords: gpcr, gem, gpcr exoframe modulator, d1r, membrane protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 88921.05

Authors

Guo, J.,Zhou, Y.,Cheng, S.,Zhang, Y. (deposition date: 2025-01-17, release date: 2026-03-04)

• Primary citation: Cheng, S.,Guo, J.,Zhou, Y.,Zhang, Y.; GPCR exoframe modulators; To Be Published,

Experimental method

ELECTRON MICROSCOPY (3 Å)