9LLI
Cryo-EM structure of D1R in complex with de novo designed GEM targeting TM1/2/4 and GEM targeting TM3/4/5, and negative allosteric GEM targeting TM5/6/7
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (R) | D(1A) dopamine receptor | polymer | 519 | 57222.9 | 1 | UniProt (P21728) | Homo sapiens (Human) | Dopamine D1 receptor |
| 2 | B (O) | De novo designed GPCR exoframe modulator targeting TM1/2/4 | polymer | 97 | 11438.8 | 1 | synthetic construct | ||
| 3 | C (P) | De novo designed GPCR exoframe modulator targeting TM3/4/5 | polymer | 77 | 8862.2 | 1 | Homo sapiens | ||
| 4 | D (Q) | De novo designed negative allosteric GPCR exoframe modulator targeting TM5/6/7 | polymer | 95 | 10962.6 | 1 | Homo sapiens | ||
| 5 | E (R) | Flupentixol | non-polymer | 434.5 | 1 | Chemie (A1EKL) |
Sequence modifications
R: 2 - 220 (UniProt: P21728)
R: 276 - 446 (UniProt: P21728)
| PDB | External Database | Details |
|---|---|---|
| Asn 163 | Trp 163 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Leu 1001 | - | linker |
| Lys 1002 | - | linker |
| Lys 1003 | - | linker |
| Glu 1004 | - | linker |
| Leu 1005 | - | linker |
| Asp 1006 | - | linker |
| Ala 1007 | - | linker |
| Leu 1008 | - | linker |
| Asn 1009 | - | linker |
| Asp 1010 | - | linker |
| Asn 1011 | - | linker |
| Trp 1012 | - | linker |
| Glu 1013 | - | linker |
| Thr 1014 | - | linker |
| Leu 1015 | - | linker |
| Asn 1016 | - | linker |
| Asp 1017 | - | linker |
| Asn 1018 | - | linker |
| Leu 1019 | - | linker |
| Lys 1020 | - | linker |
| Val 1021 | - | linker |
| Ile 1022 | - | linker |
| Glu 1023 | - | linker |
| Lys 1024 | - | linker |
| Ala 1025 | - | linker |
| Asp 1026 | - | linker |
| Asn 1027 | - | linker |
| Ala 1028 | - | linker |
| Ala 1029 | - | linker |
| Gln 1030 | - | linker |
| Val 1031 | - | linker |
| Lys 1032 | - | linker |
| Asp 1033 | - | linker |
| Ala 1034 | - | linker |
| Leu 1035 | - | linker |
| Thr 1036 | - | linker |
| Lys 1037 | - | linker |
| Met 1038 | - | linker |
| Arg 1039 | - | linker |
| Ala 1040 | - | linker |
| Ala 1041 | - | linker |
| Ala 1042 | - | linker |
| Leu 1043 | - | linker |
| Asp 1044 | - | linker |
| Ala 1045 | - | linker |
| Gln 1046 | - | linker |
| Lys 1047 | - | linker |
| Ala 1048 | - | linker |
| Thr 1049 | - | linker |
| Pro 1050 | - | linker |
| Pro 1051 | - | linker |
| Lys 1052 | - | linker |
| Leu 1053 | - | linker |
| Glu 1054 | - | linker |
| Asp 1055 | - | linker |
| Lys 1056 | - | linker |
| Ser 1057 | - | linker |
| Pro 1058 | - | linker |
| Asp 1059 | - | linker |
| Ser 1060 | - | linker |
| Pro 1061 | - | linker |
| Glu 1062 | - | linker |
| Met 1063 | - | linker |
| Lys 1064 | - | linker |
| Asp 1065 | - | linker |
| Phe 1066 | - | linker |
| Arg 1067 | - | linker |
| His 1068 | - | linker |
| Gly 1069 | - | linker |
| Phe 1070 | - | linker |
| Asp 1071 | - | linker |
| Ile 1072 | - | linker |
| Leu 1073 | - | linker |
| Val 1074 | - | linker |
| Gly 1075 | - | linker |
| Gln 1076 | - | linker |
| Ile 1077 | - | linker |
| Asp 1078 | - | linker |
| Asp 1079 | - | linker |
| Ala 1080 | - | linker |
| Leu 1081 | - | linker |
| Lys 1082 | - | linker |
| Leu 1083 | - | linker |
| Ala 1084 | - | linker |
| Asn 1085 | - | linker |
| Glu 1086 | - | linker |
| Gly 1087 | - | linker |
| Lys 1088 | - | linker |
| Val 1089 | - | linker |
| Lys 1090 | - | linker |
| Glu 1091 | - | linker |
| Ala 1092 | - | linker |
| Gln 1093 | - | linker |
| Ala 1094 | - | linker |
| Ala 1095 | - | linker |
| Ala 1096 | - | linker |
| Glu 1097 | - | linker |
| Gln 1098 | - | linker |
| Leu 1099 | - | linker |
| Lys 1100 | - | linker |
| Thr 1101 | - | linker |
| Thr 1102 | - | linker |
| Arg 1103 | - | linker |
| Asp 1104 | - | linker |
| Ala 1105 | - | linker |
| Ile 1106 | - | linker |
| Leu 1107 | - | linker |
| Lys 1108 | - | linker |
| Pro 1109 | - | linker |
| Phe 1110 | - | linker |
| Ile 1111 | - | linker |
| Glu 1112 | - | linker |
| Glu 1113 | - | linker |
| Leu 1114 | - | linker |
| Lys 1115 | - | linker |
| Glu 1116 | - | linker |
| Leu 1117 | - | linker |
| Lys 1118 | - | linker |
| Gly 1119 | - | linker |
| Lys 1120 | - | linker |
| Pro 1121 | - | linker |
| Phe 1122 | - | linker |
| Leu 1123 | - | linker |
| Ile 1124 | - | linker |
| Asp 1125 | - | linker |
| Ala 1126 | - | linker |
| Gly 447 | - | expression tag |
| Gly 448 | - | expression tag |
| Ser 449 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 88486.5 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 434.5 | |
| All* | Total formula weight | 88921.0 |
