9L89

Structure of human TREX1-DNA complex with K160R disease-associated mutation

Summary for 9L89

• Entry DOI: 10.2210/pdb9l89/pdb
• Descriptor: Three-prime repair exonuclease 1, DNA (5'-D(P*GP*TP*TP*GP*GP*CP*CP*CP*TP*CP*TP*TP*TP*AP*GP*GP*GP*CP*CP*AP*TP*C)-3') (3 entities in total)
• Functional Keywords: nuclease, dnase, innate immunity, autoimmunity, cancer, immune system/dna, immune system-dna complex
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 8
• Total formula weight: 130876.94

Authors

Zhu, J.,Wang, L.,Lin, C.,Zhou, W. (deposition date: 2024-12-27, release date: 2026-04-29)

• Primary citation: Zhu, J.,Wang, L.,Lin, C.,Zhou, W.; Distinct recognition pattern for double-stranded DNA allows TREX1 to maintain immune homeostasis; Immunity, 2026

Experimental method

X-RAY DIFFRACTION (2.38 Å)