9L89

Structure of human TREX1-DNA complex with K160R disease-associated mutation

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, E, F (A, B, E, F)	Three-prime repair exonuclease 1	polymer	242	26008.9	4	UniProt (Q9NSU2)	Homo sapiens (human)	3'-5' exonuclease TREX1,Deoxyribonuclease III,DNase III
2	C, D, G, H (C, D, G, H)	DNA (5'-D(P*GP*TP*TP*GP*GP*CP*CP*CP*TP*CP*TP*TP*TP*AP*GP*GP*GP*CP*CP*AP*TP*C)-3')	polymer	22	6710.3	4		synthetic construct
3	I, J, K, L, M... (A, B, C, D, E...)	water	water		18.0	255	Chemie (HOH)

Sequence modifications

A, B, E, F: 1 - 242 (UniProt: Q9NSU2)

PDB	External Database	Details
Arg 160	Lys 160	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	130876.9
All*	Total formula weight	130876.9

*Water molecules are not included.