9L3F

Structure-Guided Design of Picomolar-level Macrocyclic TRPC5 Channel Inhibitors with Antidepressant Activity

This is a non-PDB format compatible entry.

Summary for 9L3F

• Entry DOI: 10.2210/pdb9l3f/pdb
• EMDB information: 62784
• Descriptor: Short transient receptor potential channel 5, ZINC ION, CALCIUM ION, ... (4 entities in total)
• Functional Keywords: ion channel, trpc5, inhibitor, membrane protein
• Biological source: Mus musculus (house mouse)
• Total number of polymer chains: 4
• Total formula weight: 358208.58

Authors

Che, T.,Zhang, J.,Xiong, B.,Cheng, X.Y. (deposition date: 2024-12-18, release date: 2025-12-24)

• Primary citation: Che, T.,Zhang, J.,Xiong, B.,Cheng, X.Y.; Structure-Guided Design of Picomolar-level Macrocyclic TRPC5 Channel Inhibitors with Antidepressant Activity; To Be Published,

Experimental method

ELECTRON MICROSCOPY (3.09 Å)