9L3F
Structure-Guided Design of Picomolar-level Macrocyclic TRPC5 Channel Inhibitors with Antidepressant Activity
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Short transient receptor potential channel 5 | polymer | 765 | 88903.7 | 4 | UniProt (Q9QX29) Pfam (PF12796) Pfam (PF00023) Pfam (PF08344) Pfam (PF00520) | Mus musculus (house mouse) | TrpC5,Capacitative calcium entry channel 2,CCE2,Transient receptor protein 5,TRP-5,mTRP5,Trp-related protein 5 |
| 2 | E, H, K, N (A, B, C, D) | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
| 3 | F, I, L, O (A, B, C, D) | CALCIUM ION | non-polymer | 40.1 | 4 | Chemie (CA) | |||
| 4 | G, J, M, P (A, B, C, D) | (E)-1-(4-chlorobenzyl)-3-fluoro-1-(3-hydroxypropyl)-1,1,1,1-tetrahydro-1H-2,4-dioxa-1(8,3)-purina-3(1,3)-benzenacyclodecaphane-1,1-dione | non-polymer | 543.0 | 4 | Chemie (A1EH7) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 355614.7 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 2593.9 | |
| All* | Total formula weight | 358208.6 |
