9K2E

Crystal structure of mSMPDL3B-dimer

Summary for 9K2E

• Entry DOI: 10.2210/pdb9k2e/pdb
• Descriptor: Acid sphingomyelinase-like phosphodiesterase 3b, 2-acetamido-2-deoxy-beta-D-glucopyranose, ZINC ION, ... (5 entities in total)
• Functional Keywords: dimer, n-glycosylation, gpi-anchor, lipid-modulating phosphodiesterase., hydrolase
• Biological source: Mus musculus (house mouse)
• Total number of polymer chains: 2
• Total formula weight: 97458.82

Authors

Zhang, C.G.,Hou, Y.F.,Liu, P.Y.,Fan, S.L. (deposition date: 2024-10-17, release date: 2025-10-22)

• Primary citation: Zhang, C.G.,Hou, Y.F.; Membrane integrity changes upon viral infection activate sphingomyelinase SMPDL3B to restrict cGAS-STING signaling via cGAMP degradation; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.02 Å)