9JR3

Cryo-EM structure of PTH-PTH1R-Gq (tilted state)

Summary for 9JR3

• Entry DOI: 10.2210/pdb9jr3/pdb
• EMDB information: 61747
• Descriptor: Parathyroid hormone/parathyroid hormone-related peptide receptor, Parathyroid hormone, Guanine nucleotide-binding protein G(i) subunit alpha-1 (miniGq), ... (8 entities in total)
• Functional Keywords: class b gpcrs, gq, pth, signaling protein, signaling protein-immune system complex, signaling protein/immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 6
• Total formula weight: 169415.80

Authors

Sano, F.K.,Hirano, H.,Itoh, Y.,Nureki, O. (deposition date: 2024-09-29, release date: 2024-10-16)

• Primary citation: Sano, F.K.,Kobayashi, K.,Kawakami, K.,Akasaka, H.,Kobayashi, T.A.,Tanaka, T.,Okamoto, H.H.,Hirano, H.,Kusakizako, T.,Shihoya, W.,Kise, Y.,Itoh, Y.,Ishitani, R.,Okada, Y.,Inoue, A.,Nureki, O.; Insights into G-protein coupling preference from cryo-EM structures of Gq-bound PTH1R; To Be Published,

Experimental method

ELECTRON MICROSCOPY (2.8 Å)