9JR3
Cryo-EM structure of PTH-PTH1R-Gq (tilted state)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (R) | Parathyroid hormone/parathyroid hormone-related peptide receptor | polymer | 567 | 63846.2 | 1 | UniProt (Q03431) Pfam (PF02793) Pfam (PF00002) | Homo sapiens (human) | PTH/PTHrP type I receptor,PTH/PTHr receptor,Parathyroid hormone 1 receptor,PTH1 receptor |
| 2 | B (P) | Parathyroid hormone | polymer | 35 | 4123.8 | 1 | UniProt (P01270) Pfam (PF01279) | Homo sapiens | PTH,Parathormone,Parathyrin |
| 3 | C (A) | Guanine nucleotide-binding protein G(i) subunit alpha-1 (miniGq) | polymer | 245 | 27953.6 | 1 | Pfam (PF00503) UniProt (by SIFTS) (P63092) | Homo sapiens | |
| 4 | D (B) | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 344 | 37799.3 | 1 | UniProt (P54311) Pfam (PF00400) | Rattus rattus (black rat) | Transducin beta chain 1 |
| 5 | E (G) | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 68 | 7547.7 | 1 | UniProt (P63212) Pfam (PF00631) | Bos taurus (domestic cattle) | G gamma-I |
| 6 | F (S) | scFv16 | polymer | 260 | 27720.8 | 1 | Mus musculus | ||
| 7 | G (C) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G42666HT) | |||
| 8 | H (R) | water | water | 18.0 | 1 | Chemie (HOH) |
Sequence modifications
P: 1 - 34 (UniProt: P01270)
B: 2 - 340 (UniProt: P54311)
G: 1 - 67 (UniProt: P63212)
| PDB | External Database | Details |
|---|---|---|
| Nh2 35 | - | amidation |
| PDB | External Database | Details |
|---|---|---|
| Gly -3 | - | expression tag |
| Ser -2 | - | expression tag |
| Gln -1 | - | expression tag |
| Leu 0 | - | expression tag |
| Gln 1 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ser 68 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 168991.4 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 424.4 | |
| All* | Total formula weight | 169415.8 |
