9J6L

Solution structure of human Glutathione Peroxidase 4 (Sec73Cys) with eight mutations

Summary for 9J6L

• Entry DOI: 10.2210/pdb9j6l/pdb
• Descriptor: Phospholipid hydroperoxide glutathione peroxidase GPX4 (1 entity in total)
• Functional Keywords: ferroptosis, cancer, enzyme, peroxidase, apoptosis
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 19851.63

Authors

Furuita, K.,Sugiki, T.,Inomata, K.,Miyanoiri, Y.,Kobayashi, N.,Fujiwara, T.,Kojima, C. (deposition date: 2024-08-16, release date: 2025-08-20)

• Primary citation: Inomata, K.,Furuita, K.,Sugiki, T.,Nakada, K.,Kodama, T.S.,Miyanoiri, Y.,Kobayashi, N.,Fujiwara, T.,Kojima, C.; Glutathione Disulfide Acts as a Feedback Inhibitor of GPx4 Redox Reaction through Allosteric Regulation; To Be Published,

Experimental method

SOLUTION NMR