9J2Y

Human cGAS catalytic domain bound with G150

Summary for 9J2Y

• Entry DOI: 10.2210/pdb9j2y/pdb
• Descriptor: Cyclic GMP-AMP synthase, ZINC ION, 1-[9-(6-aminopyridin-3-yl)-6,7-dichloro-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indol-2-yl]-2-hydroxyethan-1-one, ... (4 entities in total)
• Functional Keywords: cgas, inhibitor, immune system
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 86431.86

Authors

Zhao, W.F.,Li, M.J.,Xu, Y.C. (deposition date: 2024-08-07, release date: 2025-06-04)

• Primary citation: Zhao, W.F.,Xu, Y.C.; Discovery of novel cGAS inhibitors; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.08 Å)