9J2Y

Human cGAS catalytic domain bound with G150

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Cyclic GMP-AMP synthase	polymer	366	42759.3	2	UniProt (Q8N884) Pfam (PF03281) Pfam (PF20266)	Homo sapiens (human)	cGAMP synthase,cGAS,h-cGAS,2'3'-cGAMP synthase,Mab-21 domain-containing protein 1
2	C, E (A, B)	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
3	D, F (A, B)	1-[9-(6-aminopyridin-3-yl)-6,7-dichloro-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indol-2-yl]-2-hydroxyethan-1-one	non-polymer		391.3	2	Chemie (JUJ)
4	G, H (A, B)	water	water		18.0	63	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	85518.5
Non-Polymers*	Number of molecules	4
	Total formula weight	913.3
All*	Total formula weight	86431.9

*Water molecules are not included.