9J2X

Human cGAS catalytic domain bound with RU.521

Summary for 9J2X

• Entry DOI: 10.2210/pdb9j2x/pdb
• Descriptor: Cyclic GMP-AMP synthase, 2-(4,5-dichloro-1H-benzimidazol-2-yl)-5-methyl-4-[(1R)-3-oxo-1,3-dihydro-2-benzofuran-1-yl]-1,2-dihydro-3H-pyrazol-3-one, (3~{S})-3-[1-[4,5-bis(chloranyl)-1~{H}-benzimidazol-2-yl]-3-methyl-5-oxidanyl-pyrazol-4-yl]-3~{H}-2-benzofuran-1-one, ... (5 entities in total)
• Functional Keywords: cgas, inhibitor, immune system
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 87310.28

Authors

Zhao, W.F.,Li, M.J.,Xu, Y.C. (deposition date: 2024-08-07, release date: 2025-06-04)

• Primary citation: Zhao, W.F.,Xu, Y.C.; Discovery of novel cGAS inhibitors; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.29 Å)