9J2X

Human cGAS catalytic domain bound with RU.521

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Cyclic GMP-AMP synthase	polymer	366	42759.3	2	UniProt (Q8N884) Pfam (PF03281) Pfam (PF20266)	Homo sapiens (human)	cGAMP synthase,cGAS,h-cGAS,2'3'-cGAMP synthase,Mab-21 domain-containing protein 1
2	C, G (A, B)	2-(4,5-dichloro-1H-benzimidazol-2-yl)-5-methyl-4-[(1R)-3-oxo-1,3-dihydro-2-benzofuran-1-yl]-1,2-dihydro-3H-pyrazol-3-one	non-polymer		415.2	2	Chemie (AEV)
3	D, F (A, B)	(3~{S})-3-[1-[4,5-bis(chloranyl)-1~{H}-benzimidazol-2-yl]-3-methyl-5-oxidanyl-pyrazol-4-yl]-3~{H}-2-benzofuran-1-one	non-polymer		415.2	2	Chemie (LLS)
4	E, H (A, B)	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
5	I, J (A, B)	water	water		18.0	35	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	85518.5
Non-Polymers*	Number of molecules	6
	Total formula weight	1791.7
All*	Total formula weight	87310.3

*Water molecules are not included.