9IVO

Crystal structure of KRED mutant-Y199A/N149L

Summary for 9IVO

• Entry DOI: 10.2210/pdb9ivo/pdb
• Descriptor: Short-chain dehydrogenase/reductase SDR, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, 1,2-ETHANEDIOL, ... (5 entities in total)
• Functional Keywords: kred, mutants, oxidoreductase
• Biological source: Novosphingobium aromaticivorans (strain ATCC 700278 / DSM 12444 / CCUG 56034 / CIP 105152 / NBRC 16084 / F199)
• Total number of polymer chains: 4
• Total formula weight: 109959.20

Authors

Xu, H.,Zhang, Z.,Zhang, Y.,Xu, Y.,Zhang, L. (deposition date: 2024-07-24, release date: 2025-07-30, Last modification date: 2026-07-08)

• Primary citation: Zhang, Z.,Zhang, Y.,Du, Z.,Zheng, X.,Xu, H.,Lin, Y.,Kong, P.,Li, H.,Cao, J.,Zhang, C.,Li, S.,Xu, Y.,Zhang, L.; Chemo-Enzymatic Synthesis of a Squalamine Intermediate by an Engineered Ketoreductase from Novosphingobium aromaticivorans; Acs Catalysis, 16:11618-11630, 2026; DOI: 10.1021/acscatal.6c03102

Experimental method

X-RAY DIFFRACTION (1.78 Å)