9IND

Integrin alpha-v beta-8 in complex with the Fab of 130H2

Summary for 9IND

• Entry DOI: 10.2210/pdb9ind/pdb
• EMDB information: 60703
• Descriptor: Integrin alpha-V heavy chain, The heavy chain of 130H2-Fab, The light chain of 130H2-Fab, ... (6 entities in total)
• Functional Keywords: cryo-em, integrin, complex, signaling protein/immune system, signaling protein-immune system complex
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 113715.04

Authors

Sun, H.,Zheng, Q.,Gui, X. (deposition date: 2024-07-06, release date: 2025-01-22)

Primary citation

Guo, C.,Sun, H.,Du, Y.,Dai, X.,Pang, Y.,Han, Z.,Xiong, X.,Li, S.,Zhang, J.,Zheng, Q.,Gui, X.
Specifically blocking alpha v beta 8-mediated TGF-beta signaling to reverse immunosuppression by modulating macrophage polarization.
J Exp Clin Cancer Res, 44:1-1, 2025

PubMed Abstract: Targeting the TGF-β pathway in tumor therapy has proven challenging due to the highly context-dependent functions of TGF-β. Integrin αvβ8, a pivotal activator of TGF-β, has been implicated in TGF-β signaling within tumors, as demonstrated by the significant anti-tumor effects of anti-αvβ8 antibodies. Nevertheless, the expression profile of αvβ8 remains a subject of debate, and the precise mechanisms underlying the anti-tumor effects of anti-αvβ8 antibodies are not yet fully elucidated.

PubMed: 39743547
DOI: 10.1186/s13046-024-03250-1

Experimental method

ELECTRON MICROSCOPY (2.88 Å)