9IK9

Cryo-EM Structure of SST analogs bond SSTR1-Gi complex

Summary for 9IK9

• Entry DOI: 10.2210/pdb9ik9/pdb
• EMDB information: 60651
• Descriptor: Guanine nucleotide-binding protein G(i) subunit alpha-1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (6 entities in total)
• Functional Keywords: sstr1, sst analogs, membrane protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 6
• Total formula weight: 169618.23

Authors

Wong, T.S.,Zeng, Z.C.,Xiong, T.T.,Gan, S.Y.,Du, Y. (deposition date: 2024-06-26, release date: 2025-04-30)

• Primary citation: Zeng, Z.,Liao, Q.,Gan, S.,Li, X.,Xiong, T.,Xu, L.,Li, D.,Jiang, Y.,Chen, J.,Ye, R.,Du, Y.,Wong, T.; Structural insights into the binding modes of lanreotide and pasireotide with somatostatin receptor 1; Acta Pharm Sin B, 2025; DOI: 10.1016/j.apsb.2025.03.043

Experimental method

ELECTRON MICROSCOPY (3.37 Å)