9I64

Crystal structure of Casdatifan bound to HIF2a-B:ARNT-B complex

Summary for 9I64

Entry DOI	10.2210/pdb9i64/pdb
Descriptor	Endothelial PAS domain-containing protein 1, Aryl hydrocarbon receptor nuclear translocator, (5~{R},6~{S},8~{R})-3,5,6-tris(fluoranyl)-8-[(1~{S},2~{R})-2-fluoranyl-7-methylsulfonyl-1-oxidanyl-2,3-dihydro-1~{H}-inden-4-yl]-5,6,7,8-tetrahydronaphthalene-1-carbonitrile, ... (6 entities in total)
Functional Keywords	hif-2a inhibitor, casdatifan, ab521, clear cell renal cell carcinoma (ccrcc), hypoxia, transcription
Biological source	Homo sapiens (human) More
Total number of polymer chains	2
Total formula weight	27199.85
Authors	Walker, N.P.,Lawson, K.V. (deposition date: 2025-01-29, release date: 2026-02-18)
Primary citation	Walker, N.P.,Lawson, K.V. Discovery of Casdatifan Part II, A Potent and Orally Bioavailable Inhibitor of Hypoxia Inducible Factor-2a To Be Published,
Experimental method	X-RAY DIFFRACTION (1.558 Å)

Structure validation