9I64
Crystal structure of Casdatifan bound to HIF2a-B*:ARNT-B* complex
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Endothelial PAS domain-containing protein 1 | polymer | 112 | 12992.6 | 1 | UniProt (Q99814) Pfam (PF14598) | Homo sapiens (human) | EPAS-1,Basic-helix-loop-helix-PAS protein MOP2,Class E basic helix-loop-helix protein 73,bHLHe73,HIF-1-alpha-like factor,HLF,Hypoxia-inducible factor 2-alpha,HIF-2-alpha,HIF2-alpha,Member of PAS protein 2,PAS domain-containing protein 2 |
| 2 | B (B) | Aryl hydrocarbon receptor nuclear translocator | polymer | 116 | 13697.4 | 1 | UniProt (P27540) Pfam (PF14598) | Homo sapiens (human) | ARNT protein,Class E basic helix-loop-helix protein 2,bHLHe2,Dioxin receptor,nuclear translocator,Hypoxia-inducible factor 1-beta,HIF-1-beta,HIF1-beta |
| 3 | C (A) | (5~{R},6~{S},8~{R})-3,5,6-tris(fluoranyl)-8-[(1~{S},2~{R})-2-fluoranyl-7-methylsulfonyl-1-oxidanyl-2,3-dihydro-1~{H}-inden-4-yl]-5,6,7,8-tetrahydronaphthalene-1-carbonitrile | non-polymer | 439.4 | 1 | Chemie (A1I0H) | |||
| 4 | D (A) | FORMIC ACID | non-polymer | 46.0 | 1 | Chemie (FMT) | |||
| 5 | E (B) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 6 | F, G (A, B) | water | water | 18.0 | 202 | Chemie (HOH) |
Sequence modifications
A: 240 - 350 (UniProt: Q99814)
B: 355 - 470 (UniProt: P27540)
| PDB | External Database | Details |
|---|---|---|
| Ser 239 | - | expression tag |
| Glu 247 | Arg 247 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Arg 362 | Glu 362 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 26690.1 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 509.8 | |
| All* | Total formula weight | 27199.8 |
