9I5E

A Coiled Coil Module Strategy for High-Resolution Cryo-EM Structures of Small Proteins for Drug Discovery

Summary for 9I5E

• Entry DOI: 10.2210/pdb9i5e/pdb
• EMDB information: 52628
• Descriptor: Isoform 2B of GTPase KRas,APH2, Nanobody 26, {(2S)-4-[7-(8-chloronaphthalen-1-yl)-2-{[(2S)-1-methylpyrrolidin-2-yl]methoxy}-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-yl]-1-[(2S)-2-fluoropropanoyl]piperazin-2-yl}acetonitrile, ... (5 entities in total)
• Functional Keywords: cryoem imaging scaffold, cancer, gtpase, nanobodies, coiled-coil, structural protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 76196.29

Authors

Samson, C.,Dossou, I.,Steinmetz, A.,Kumar, A.,Mathieu, M.,Rak, A. (deposition date: 2025-01-28, release date: 2025-11-12)

• Primary citation: Samson, C.,Dossou, I.,Steinmetz, A.,Kumar, A.,Mathieu, M.,Rak, A.; A Coiled Coil Module Strategy for High-Resolution Cryo-EM Structures of Small Proteins for Drug Discovery; To Be Published,

Experimental method

ELECTRON MICROSCOPY (3.77 Å)