9I5E
A Coiled Coil Module Strategy for High-Resolution Cryo-EM Structures of Small Proteins for Drug Discovery
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, D (A, B) | Isoform 2B of GTPase KRas,APH2 | polymer | 204 | 23465.7 | 2 | UniProt (P01116) Pfam (PF00071) | Homo sapiens (human) | K-Ras 2,Ki-Ras,c-K-ras,c-Ki-ras |
| 2 | B, C (M, N) | Nanobody 26 | polymer | 122 | 13558.9 | 2 | Lama glama | ||
| 3 | E, J (A, B) | {(2S)-4-[7-(8-chloronaphthalen-1-yl)-2-{[(2S)-1-methylpyrrolidin-2-yl]methoxy}-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-yl]-1-[(2S)-2-fluoropropanoyl]piperazin-2-yl}acetonitrile | non-polymer | 606.1 | 2 | Chemie (M1X) PubChem (146020603) PubChem (147131018) | |||
| 4 | F, H (A, B) | GUANOSINE-5'-DIPHOSPHATE | non-polymer | 443.2 | 2 | Chemie (GDP) PubChem (136073927) PubChem (135398619) PubChem (135402030) PubChem (135431654) PubChem (135566337) PubChem (135760556) PubChem (136026707) PubChem (136053418) PubChem (136663964) PubChem (136664748) PubChem (136759848) PubChem (136759849) PubChem (136759850) PubChem (136836636) PubChem (136847074) PubChem (172898537) | |||
| 5 | G, I (A, B) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) PubChem (888) |
Sequence modifications
A, B: 1 - 164 (UniProt: P01116)
A, B: 165 - 204 (PDB: 9I5E)
| PDB | External Database | Details |
|---|---|---|
| Cys 12 | Gly 12 | variant |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 74049.0 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 2147.3 | |
| All* | Total formula weight | 76196.3 |
