9I1Q

HER3 receptor in complex with the Fab fragment of TK-hu A3 monoclonal antibody

Summary for 9I1Q

• Entry DOI: 10.2210/pdb9i1q/pdb
• Descriptor: Receptor tyrosine-protein kinase erbB-3, light chain hA3-Fab, heavy chain hA3-Fab, ... (9 entities in total)
• Functional Keywords: growth factor receptor, monoclonal antibody, cancer, complex, antitumor protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 12
• Total formula weight: 480995.45

Authors

Bulfaro, G.,Savino, C.,Costanzo, A.,Fata, F.,Vallone, B.,Montemiglio, L.C. (deposition date: 2025-01-16, release date: 2025-10-15, Last modification date: 2025-11-05)

Primary citation

Muzi, A.,Arriga, R.,Bulfaro, G.,Fata, F.,Costanzo, A.,Chiarini, V.,Cappelletti, M.,Ferrara, F.F.,Bucci, F.,Montemiglio, L.C.,Savino, C.,Marra, E.,Ciliberto, G.,Aurisicchio, L.,Vallone, B.,Roscilli, G.
Novel Humanized Anti-HER3 Antibodies: Structural Characterization and Therapeutic Activity.
Antibodies, 14:-, 2025

PubMed Abstract: The ErbB protein family plays a critical role in the progression of various solid tumors, and HER3 has been implicated in resistance mechanisms to multiple cancer therapies due to its ability to form heterodimers with other ErbB receptors, thereby activating pathways that promote tumor growth and survival. This study aimed to generate and characterize humanized monoclonal antibodies against HER3 to inhibit its function and evaluate their potential as therapeutic agents.

PubMed: 41133678
DOI: 10.3390/antib14040084

Experimental method

X-RAY DIFFRACTION (2.8 Å)