9I1Q

HER3 receptor in complex with the Fab fragment of TK-hu A3 monoclonal antibody

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	Receptor tyrosine-protein kinase erbB-3	polymer	632	69786.1	4	UniProt (P21860) Pfam (PF01030) Pfam (PF00757) Pfam (PF14843)	Homo sapiens (human)	Proto-oncogene-like protein c-ErbB-3,Tyrosine kinase-type cell surface receptor HER3
2	E, F, G, H (E, F, G, H)	light chain hA3-Fab	polymer	220	24244.0	4		Homo sapiens
3	I, J, K, L (I, J, K, L)	heavy chain hA3-Fab	polymer	223	24068.2	4		Homo sapiens
4	M, O (M, O)	beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		586.5	2	In PDB GlyTouCan (G15407YE)
5	N (N)	alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		748.7	1	In PDB GlyTouCan (G22573RC)
6	P, Q (P, Q)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	2	In PDB GlyTouCan (G42666HT)
7	AA, BA, CA, EA, FA... (B, C, D, A)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	24	Chemie (NAG)
8	DA, JA, RA, SA, TA... (B, C, D, H, I...)	THIOCYANATE ION	non-polymer		58.1	9	Chemie (SCN)
9	AB, BB, CB, DB, EB... (C, D, E, F, G...)	water	water		18.0	105	Chemie (HOH)

Sequence modifications

A, B, C, D: 1 - 624 (UniProt: P21860)

PDB	External Database	Details
Val 625	-	expression tag
Asp 626	-	expression tag
His 627	-	expression tag
His 628	-	expression tag
His 629	-	expression tag
His 630	-	expression tag
His 631	-	expression tag
His 632	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	12
	Total formula weight	472393.2
Branched	Number of molecules	5
	Total formula weight	2770.6
Non-Polymers*	Number of molecules	33
	Total formula weight	5831.7
All*	Total formula weight	480995.5

*Water molecules are not included.