9I0T

Crystal structure of TRIM25 PRYSPRY covalently bound to 2-chloro-1-[4-(3-methyl-4-phenyl-phenyl)carbonyl-1,4-diazepan-1-yl]ethanone

This is a non-PDB format compatible entry.

Summary for 9I0T

• Entry DOI: 10.2210/pdb9i0t/pdb
• Descriptor: E3 ubiquitin/ISG15 ligase TRIM25, 1-[4-(3-methyl-4-phenyl-phenyl)carbonyl-1,4-diazepan-1-yl]ethanone (3 entities in total)
• Functional Keywords: ubiquitin, e3 ligase, small molecule ligand, pryspry, ligase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 23031.62

Authors

McPhie, K.A.,Esposito, D.,Rittinger, K. (deposition date: 2025-01-15, release date: 2025-05-21)

• Primary citation: McPhie, K.A.,Esposito, D.,Pettinger, J.P.,Norman, D.,Werner, T.,Bush, J.T.,Rittinger, K.; Discovery and optimisation of a covalent ligand for TRIM25 and its application to targeted protein ubiquitination; Chem Sci, 2025; DOI: 10.1039/D5SC01540E

Experimental method

X-RAY DIFFRACTION (1.8 Å)