9HYK

Crystal structure of Trypanosoma brucei trypanothione reductase (TbTR) bound to PROTAC-1

This is a non-PDB format compatible entry.

Summary for 9HYK

• Entry DOI: 10.2210/pdb9hyk/pdb
• Descriptor: Trypanothione reductase, FLAVIN-ADENINE DINUCLEOTIDE, N-(3-((S)-6-chloro-2-methyl-4-phenylquinazolin-3(4H)-yl)propyl)-2-(2-(2-((2-((3~{R})-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethoxy)acetamide, ... (4 entities in total)
• Functional Keywords: trypanothione reductase, protac, oxidoreductase
• Biological source: Trypanosoma brucei
• Total number of polymer chains: 4
• Total formula weight: 219994.86

Authors

Exertier, C.,Ilari, C.,Fiorillo, A. (deposition date: 2025-01-10, release date: 2026-07-22)

• Primary citation: Salerno, A.,Exertier, C.,Fiorillo, A.,Pasieka, A.,Ocello, R.,Morea, V.,Altomare, A.,Uliassi, E.,Milleli, A.,Aldini, G.,Di Muccio, T.,Ilari, A.,Bolognesi, M.L.; Unlocking Targeted Protein Degradation in Parasites: A Chemical Approach to Address Trypanothione Reductase in Leishmania infantum; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.09 Å)