9HYK
Crystal structure of Trypanosoma brucei trypanothione reductase (TbTR) bound to PROTAC-1
This is a non-PDB format compatible entry.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004791 | molecular_function | thioredoxin-disulfide reductase (NADPH) activity |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0015042 | molecular_function | trypanothione-disulfide reductase (NADPH) activity |
| A | 0020015 | cellular_component | glycosome |
| A | 0020023 | cellular_component | kinetoplast |
| A | 0031981 | cellular_component | nuclear lumen |
| A | 0045454 | biological_process | cell redox homeostasis |
| A | 0097014 | cellular_component | ciliary plasm |
| A | 0098869 | biological_process | cellular oxidant detoxification |
| B | 0004791 | molecular_function | thioredoxin-disulfide reductase (NADPH) activity |
| B | 0005654 | cellular_component | nucleoplasm |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0015042 | molecular_function | trypanothione-disulfide reductase (NADPH) activity |
| B | 0020015 | cellular_component | glycosome |
| B | 0020023 | cellular_component | kinetoplast |
| B | 0031981 | cellular_component | nuclear lumen |
| B | 0045454 | biological_process | cell redox homeostasis |
| B | 0097014 | cellular_component | ciliary plasm |
| B | 0098869 | biological_process | cellular oxidant detoxification |
| C | 0004791 | molecular_function | thioredoxin-disulfide reductase (NADPH) activity |
| C | 0005654 | cellular_component | nucleoplasm |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0015042 | molecular_function | trypanothione-disulfide reductase (NADPH) activity |
| C | 0020015 | cellular_component | glycosome |
| C | 0020023 | cellular_component | kinetoplast |
| C | 0031981 | cellular_component | nuclear lumen |
| C | 0045454 | biological_process | cell redox homeostasis |
| C | 0097014 | cellular_component | ciliary plasm |
| C | 0098869 | biological_process | cellular oxidant detoxification |
| D | 0004791 | molecular_function | thioredoxin-disulfide reductase (NADPH) activity |
| D | 0005654 | cellular_component | nucleoplasm |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0015042 | molecular_function | trypanothione-disulfide reductase (NADPH) activity |
| D | 0020015 | cellular_component | glycosome |
| D | 0020023 | cellular_component | kinetoplast |
| D | 0031981 | cellular_component | nuclear lumen |
| D | 0045454 | biological_process | cell redox homeostasis |
| D | 0097014 | cellular_component | ciliary plasm |
| D | 0098869 | biological_process | cellular oxidant detoxification |
Functional Information from PROSITE/UniProt
| site_id | PS00076 |
| Number of Residues | 11 |
| Details | PYRIDINE_REDOX_1 Pyridine nucleotide-disulphide oxidoreductases class-I active site. GGtCVnvGCVP |
| Chain | Residue | Details |
| A | GLY49-PRO59 |
